The original context of the meme, Rage Comics was to humor others with your ridiculous stories that may or may not have happened to you. The rage comics use a different language tied in with the cultural norms that we all understand to create humor. Using derp or herp in the rage comics is also a form humor showing social indifference by not caring. In actuality derp is used to represent stupidity, but in the rage comics it is used as expression to represent unimportant dialogue, just as blah blah is used. For example, in almost every comic there is going to be some form of derp or herp. This meme in my opinion has made its own statement because it has certain words that are used in the comics that mean certain things. This character is usually used in a situation responding to an awkward or disgusting event. This shows a cultural difference because you do not need to know Spanish to know what me gusta mean. One known cultural reference that the rage comics represent is the me gusta guy. Usually at the end of a comic there is a punch line (rage face) that represents an emotion because of the situation that just occurred. The responses are displayed through the rage faces and rage characters.
In normal life one person may do something and expect a certain response, well in the rage comics it is similar.
The cultural reference in these Rage Comics is used to make fun of society resulting in humor. For example, the forever alone guy represents disappointment and loneliness in life and may be used in a comic where a person goes through a break up.